ArticleAdvanced healthcare materials2025
Development of Substrate-Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross-Linked Hydrogel Coatings for Biomedical Applications.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Machine learning-advanced hydrogel-based transcription-coupled positive-feedback CRISPR/Cas13a analysis for novel microRNA signatures in differential diagnosis of non-small cell lung cancer.Journal of nanobiotechnology · 2026Article
- Zwitterionic multifunctional coatings with strong hydration for ureteral stents to inhibit infectious encrustation.Bioactive materials · 2026Article
- Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential.Gels (Basel, Switzerland) · 2025Review
- Development of Substrate-Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross-Linked Hydrogel Coatings for Biomedical Applications.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Preventing biofouling and bacterial infections are pivotal issues in developing implantable biomaterials. Zwitterionic hydrogels stand out for their antifouling effects and high biocompatibility, making them ideal for biomedical applications. However, the lack of direct bactericidal activity and the limited applicability to various materials are key challenges to be addressed in these hydrogel coatings. To address this, a dual-functional hydrogel coating with synergetic antifouling and biocidal properties is proposed to prevent the initial infection and consequent biofilm formation, which can be applied to various types of substrates. This coating is fabricated via photo-crosslinking, combining representative zwitterionic polymer, poly (sulfobetaine methacrylate) (pSBMA), with a cationic bactericidal polymer, poly (2-aminoethyl methacrylate) (pAEMA). Owing to antifouling and contact-killing properties, the p(SBMA-co-AEMA) hydrogel-coated surface can repel non-specific proteins and eradicate bacteria such as E. coli and S. aureus that overcame the antifouling barrier. These results also demonstrate that this hydrogel coating exhibits excellent biocompatibility and can be applied to various substrate materials from polymers to metals. The coating method developed in this study holds great potential for enhancing the performance and safety of various implantable biomaterials and medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.