Evidence map›Paper›PMID 40522063›Full record

ArticleJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025

Associations Between Dietary Carotenoid Intake and Plasma Carotenoid Concentrations and Skin Yellowness, a Validation Study.

Erin D Clarke, Mitch J Duncan, Tracy Burrows, María Gómez-Martín, Katherine Brain, Jordan Stanford, Jessica J A Ferguson, Lisa Wood, Clare E Collins

Abstract readValidation Study
In one paragraph

Article in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erin D ClarkeSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8250-5990
Mitch J DuncanSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9166-6195
Tracy BurrowsSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0002-1431-7864
María Gómez-MartínSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.
Katherine BrainSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.
Jordan StanfordSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.
Jessica J A FergusonSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7962-1840
Lisa WoodSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.
Clare E CollinsSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3298-756X

Funding

This work was supported by the National Health and Medical Research Council of Australia Research Fellowships (APP1173681 and APP2009340).
6 · The paper itself

Abstract

backgroundCarotenoids are pigments abundant in fruits and vegetables and can be measured in plasma and skin. This study aimed to evaluate associations between carotenoid intake, assessed by self-reported usual diet against plasma carotenoid and skin yellowness concentrations in Australian adults (n = 50, aged 39.3 ± 15.4 years, 68% female).

methodsDietary carotenoid intakes were quantified using the Australian Eating Survey (AES) food frequency questionnaire (total, α- and β-carotene, lycopene, β-cryptoxanthin, and lutein/zeaxanthin). Plasma concentrations of these carotenoids were measured using high-performance liquid chromatography, while skin yellowness was measured using skin reflectance spectroscopy as a proxy for skin carotenoids. Associations between AES carotenoids, plasma carotenoids and total skin yellowness were analysed using linear regressions.

resultsAES-derived carotenoid intakes were positively associated with skin yellowness for all dietary carotenoids (β range 0.25-0.46, p < 0.05) and total dietary carotenoids (β = 0.35 [95% CI 0.07, 0.63], p < 0.05), except lycopene. Similarly, each individual plasma carotenoid was significantly positively associated with their respective individual dietary carotenoids (β range 0.42-0.53, p < 0.05) and total dietary carotenoids (β = 0.38 [95% CI 0.04, 0.73], p < 0.05), except for lycopene. Significant positive associations were identified between skin yellowness and total (β = 0.36 [0.20, 0.52], p < 0.001) and individual plasma carotenoids (β range 0.30-0.37, p < 0.01), excluding α-carotene and lycopene.

conclusionDietary carotenoid intakes were significantly associated with plasma carotenoid concentrations and skin yellowness values. Results support use of all three methods for assessment of carotenoid intake, with the exception of lycopene. Future studies should consider cost, accessibility of assessment methods and participant burden when selecting dietary assessment methods.

trial registrationThe original study was registered with Australian New Zealand Clinical Trials Registry (ANZCTR-12619001415190).

Indexed as

CarotenoidsDietSkinSkin PigmentationAdultAustraliabeta CaroteneChromatography, High Pressure LiquidDiet SurveysFemaleFruitHumansLycopeneMaleMiddle AgedSelf Reportbeta CaroteneCarotenoidsLycopenedietary assessmentdietary carotenoidsskin carotenoidsvalidation study

Identifiers

PMID40522063
PMCPMC12169085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.