Trial reportPhysiological reports2025
Glucose ingestion increases passive absorption of a nutrient-sized solute, mannitol, in healthy young adults.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glucose ingestion increases passive absorption of a nutrient-sized solute, mannitol, in healthy young adults.Physiological reports · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Active glucose absorption increases passive, paracellular absorption of small solutes. Absorption of larger molecules by this mechanism has not been verified in humans under physiological conditions. The purpose of this study was to determine if ingestion of a glucose solution enhances absorption of mannitol in humans. Mannitol (182 Da) is a non-metabolizable molecule believed to be absorbed only via the paracellular route. Its urinary excretion therefore may serve as an index for paracellular absorption of similar-sized solutes, such as glucose (180 Da) and amino acids (average 138 Da). Eight healthy individuals (five females, three males; mean age = 22 +/- 1 yrs) ingested a 4% glucose/0.2% mannitol solution or a 4% fructose/0.2% mannitol solution using a randomized, balanced design. Urine was collected for 5 h and mannitol excretion determined. Ingestion of the glucose solution increased (p < 0.05) mannitol excretion (0.52 +/-0.27 g) compared to the fructose solution (0.39 +/-0.13 g), a 33% increase. These results indicate glucose promotes passive absorption of nutrient-sized solutes, likely via the paracellular route. This may explain how humans can absorb high amounts of glucose when maximal active transport is exceeded. Furthermore, other nutrients such as amino acids may utilize this route, thereby enhancing absorption.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.