Evidence map›Paper›PMID 40521898›Full record

ArticleVirulence2025

Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.

Hankun Wang, Chunling Zhang, Moran Li, Wangchun Zhao, Jialin Wang, Yanhong Ran, Xiaoping Yang, Zemin Deng, Jun Chen, Hongjian Li

Abstract read
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In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hankun WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Chunling ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Moran LiDepartment of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Wangchun ZhaoDepartment of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Jialin WangDepartment of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Yanhong RanDepartment of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Xiaoping YangDepartment of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Zemin DengState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Jun ChenState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID 0000-0003-2447-0544
Hongjian LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID 0000-0003-2143-7079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a typical opportunistic human pathogen, which can endanger the lives of individuals with immune insufficiency or low immune function. One of the most effective immune mechanisms against HCMV in host cells is the production of antiviral cytokines. Chemokines are small secreted proteins produced by cell immune responses to inflammatory stimuli or viral infection and act as potent chemoattractants for granulocytes, monocytes, lymphocytes and other leukocytes, and thus play a significant role in antiviral defence. Viruses have also evolved multiple strategies to resist the host's immune system while coexisting with the host. In this study, based on RNA sequencing transcriptome differential analysis, we found that HCMV encoded UL23 May specifically down-regulate chemokines Chemokine ligand 2 (CCL2) and Chemokine ligand 5 (CCL5). Next, we determined that UL23 could inhibit the expression of Chemokine CCL2 and CCL5 by mainly affecting the phosphorylation of IRF-3, and then inhibited the migration of immune cells and blocked the antiviral immune responses in the migration and co-culture assays of HCMV-infected cells with immune migration-related cells. In conclusion, these results highlight that UL23 plays an important role in the immune evasion of HCMV by specially inhibiting the expression of chemokines CCL2 and CCL5, impairing the recruitment of immune cells by infected host cells and helping the virus escape immune killing.

Indexed as

Cell MovementChemokine CCL2Chemokine CCL5CytomegalovirusImmune EvasionViral ProteinsCytomegalovirus InfectionsHost-Pathogen InteractionsHumansCCL2 protein, humanCCL5 protein, humanChemokine CCL2Chemokine CCL5Viral Proteinschemokine ligand 2, CCL2chemokine ligand 5, CCL5Human cytomegalovirus, HCMVUL23

Identifiers

PMID40521898
PMCPMC12184176

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.