Evidence map›Paper›PMID 40521810›Full record

ArticleChemical research in toxicology2025

Untargeted DNA Adductomics Identifies Aristolochic Acid III as a Potent DNA-Damaging Agent among 11 Substituted Aromatic Genotoxicants in the Rat Urinary System.

Medjda Bellamri, Scott J Walmsley, Lihua Yao, Thomas A Rosenquist, Christopher J Weight, Peter W Villalta, Robert J Turesky

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lihua Yao
Thomas A RosenquistDepartment of Pharmacological Science, Stony Brook University, Stony Brook, New York 11794, United States.
Christopher J WeightDepartment of Urology, Cleveland Clinic, Cleveland, Ohio 44195, United States.

Funding

Untargeted Analysis ResourceU2CES026533 · NIEHS · UNIVERSITY OF MINNESOTA · PI PETERSON, LISA A · 2015 to 2025
$14.0M
DNA adductomics of the urinary systemR01CA220367 · NCI · UNIVERSITY OF MINNESOTA · PI ROSENQUIST, THOMAS A, TURESKY, ROBERT J. · 2017 to 2022
$3.0M
DNA adductome of human bladder from the tobacco exposomeR01ES030559 · NIEHS · UNIVERSITY OF MINNESOTA · PI TURESKY, ROBERT J. · 2019 to 2023
$2.3M
Kidney DNA AdductomicsR01ES030765 · NIEHS · UNIVERSITY OF MINNESOTA · PI BALBO, SILVIA, TURESKY, ROBERT J. · 2020 to 2024
$2.2M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
NCI NIH HHS R01 CA220367NCI NIH HHS R50 CA211256NIEHS NIH HHS R01 ES030559NIEHS NIH HHS R01 ES030765NIEHS NIH HHS U2C ES026533
6 · The paper itself

Abstract

An untargeted, data-independent acquisition high-resolution accurate tandem mass spectrometry method using an Orbitrap mass spectrometer was employed to screen for DNA adducts formed from 11 environmental and dietary aromatic or substituted aromatic carcinogens in the kidney, urinary bladder, prostate, pancreas, liver, and the lung of male rats 24 h after treatment. Among the carcinogens investigated, DNA adducts of the structurally related nitrophenanthrenes 3-nitrobenzanthrone (3-NBA), an atmospheric pollutant, and 8-methoxy-6-nitrophenanthro[3,4-

Indexed as

Aristolochic AcidsDNA AdductsDNA DamageMutagensAnimalsCarcinogensMaleRatsRats, Sprague-DawleyTandem Mass SpectrometryAristolochic AcidsCarcinogensDNA AdductsMutagens

Identifiers

PMID40521810
PMCPMC12263058

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.