Evidence map›Paper›PMID 40521778›Full record

ArticleAnnals of neurology2025

Clinical and Cognitive Profiles of Individuals with Alzheimer's Disease and Comorbid Seizures.

Anny Reyes, Ifrah Zawar, Vineet Punia, Rani A Sarkis, Jaideep Kapur, Robyn M Busch, Mark W Bondi, David P Salmon, Bruce P Hermann, Carrie R McDonald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anny ReyesDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0625-6990
Ifrah ZawarEpilepsy Division, Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Vineet PuniaEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0552-6736
Rani A SarkisEpilepsy Division, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8291-7864
Jaideep KapurEpilepsy Division, Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-8608-1352
Robyn M BuschEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-5442-4912
Mark W BondiDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
David P SalmonDepartment of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA, USA.
Bruce P HermannDepartment of Neurology, Health Sciences Learning Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Carrie R McDonaldDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA.

Funding

National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BRADFORD C DICKERSON · 2019 to 2026
$36.5M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Alzheimer's Association AACSFD-22-974008American Epilepsy Society 1067206Burroughs Wellcome Fund, Postdoctoral Diversity Enrichment ProgramNational Academy of Neuropsychology, Clinical Research GrantNIA NIH HHS K23 AG084893NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG079280NIA NIH HHS U24 AG072122NIH HHS 1K23AG084893-01A1NIH HHS P30AG062429NIH HHS R01-NS111022NIH HHS R01-NS117568NIH HHS R01 NS120976NIH HHS R01NS123378NINDS NIH HHS L60 NS134003NINDS NIH HHS R01 NS111022NINDS NIH HHS R01 NS117568NINDS NIH HHS R01 NS120976NINDS NIH HHS R01 NS123378
6 · The paper itself

Abstract

objectiveSeizures are a highly prevalent comorbidity in Alzheimer's disease (AD), with a 2- to 6-fold increased risk, and are associated with accelerated cognitive decline. Despite growing research on seizure detection and treatment in AD, the cognitive profiles of individuals with both AD and seizures remain poorly characterized using comprehensive neuropsychological methods.

methodsClinical and cognitive data from individuals age 65+ with AD were analyzed from the National Alzheimer's Coordinating Center (NACC) dataset. Cognitive domains assessed included memory, language, attention, processing speed, and executive function. Raw scores were converted into z-scores using a control sample (n = 14,665). Group comparisons were conducted using independent t tests, χ

resultsAmong 9,662 individuals with AD, 1.2% (n = 117) had active seizures (AD-S). The AD-S group was younger, had higher stroke and transient ischemic attack rates, earlier cognitive decline, longer symptom duration, cognitive fluctuations, abrupt cognitive changes, and worse cognitive and functional outcomes. Cognitive deficits in AD-S, particularly in executive function and processing speed, persisted after adjusting for dementia severity. Compared to vascular dementia, AD-S individuals exhibited greater impairments in fluency, naming, and processing speed.

interpretationComorbid AD and seizures are associated with distinct cognitive and clinical profiles, greater vascular disease burden, and more severe dementia. Findings emphasize the need for early seizure detection, comprehensive cognitive evaluations, and research on cerebrovascular contributions to inform targeted interventions. ANN NEUROL 2025;98:533-546.

Indexed as

Alzheimer DiseaseCognitive DysfunctionSeizuresAgedAged, 80 and overComorbidityExecutive FunctionFemaleHumansMaleNeuropsychological Tests

Identifiers

PMID40521778
PMCPMC12690363

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.