Evidence map›Paper›PMID 40521743›Full record

ArticleAnalytical chemistry2025

Structure Elucidation for MALDI Mass Spectrometry Imaging Using Infrared Ion Spectroscopy.

Jelle L Schuurman, Lara van Tetering, Kas J Houthuijs, Pieter Kooijman, Valerie Gailus-Durner, Stefanie Leuchtenberger, Helmut Fuchs, Martin Hrabe de Angelis, Udo F H Engelke, Dirk J Lefeber and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jelle L SchuurmanHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0009-0005-0617-9253
Lara van TeteringHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0009-0003-5070-6116
Kas J HouthuijsHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-8205-2896
Pieter KooijmanHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.
Valerie Gailus-DurnerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Stefanie LeuchtenbergerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Helmut FuchsInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Martin Hrabe de AngelisInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Udo F H EngelkeTranslational Metabolic Laboratory, Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Dirk J LefeberTranslational Metabolic Laboratory, Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Clara D M van KarnebeekEmma Center for Personalized Medicine Department of Paediatrics, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.
Ron A WeversTranslational Metabolic Laboratory, Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Andrej GrgicMultimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.
Benjamin BallufMultimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.
Michiel VandenboschMultimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-0427-416X
Rob VreekenMultimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0003-3568-1371
Ron M A HeerenMultimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-6533-7179
Giel BerdenHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0003-1500-922X
Jos OomensHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-2717-1278
Jonathan MartensHFML-FELIX, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0001-9537-4117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infrared ion spectroscopy (IRIS) is a tandem mass spectrometry (MS) technique that generates structurally diagnostic vibrational spectra for mass-selected ions trapped in a mass spectrometer. Until now, IRIS applications for biological samples have primarily focused on solution-based analyses, such as body fluids (e.g., plasma and urine) and tissue homogenates, using electrospray ionization (ESI) coupled with liquid chromatography-mass spectrometry (LC-MS). In this study, we have combined matrix-assisted laser desorption/ionization (MALDI) with IRIS for the direct analysis of small molecules from biological tissues on a Fourier-transform ion cyclotron resonance mass spectrometer. We applied this technique alongside MALDI mass spectrometry imaging to analyse brain tissue from two knockout mouse models of l-lysine catabolism disorders: pyridoxine-dependent epilepsy (

Indexed as

Amino Acid Metabolism, Inborn ErrorsBrain Diseases, MetabolicEpilepsyMetabolomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Near-InfraredAldehyde DehydrogenaseAnimalsBrainGlutaryl-CoA DehydrogenaseMiceMice, KnockoutAldehyde DehydrogenaseAldh7a1 protein, mouseGlutaryl-CoA Dehydrogenase

Identifiers

PMID40521743
PMCPMC12224163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.