SynthesisPain practice : the official journal of World Institute of Pain2025
Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.
Synthesis in Pain practice : the official journal of World Institute of Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.Pain practice : the official journal of World Institute of Pain · 2025Pooled it
- Cryotherapy combined with standard rehabilitation and early functional recovery after knee arthroplasty: a retrospective cohort study.BMC musculoskeletal disorders · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo update knowledge on the effects of cryotherapy in reducing pain, increasing strength, and improving function in patients with knee osteoarthritis.
methodsThe databases used included PubMed, Embase, Cochrane, Physiotherapy Evidence Database (PEDro), Scopus, Web of Science, and LILACS. In addition, gray literature was searched in Google Scholar, LIVIVO, Open Gray, and the CAPES Library of Theses and Dissertations. The risk of bias was assessed using the Cochrane tool, RoB 2, by two independent reviewers, with conflicts being resolved by consensus. The primary outcome was pain, while secondary outcomes included functionality and muscle strength.
resultsFive randomized controlled trials were selected from 2094 initial registrations. The meta-analysis included all five studies in the pain intensity outcome, resulting in a standardized mean difference (SMD) of -0.57 (95% CI: [-0.97, -0.18]; p = 0.004; I
conclusionThese findings indicate that cryotherapy can be useful as part of a comprehensive treatment for knee osteoarthritis, especially when combined with kinesiotherapy, but its effectiveness as a stand-alone treatment still requires further studies with a lower risk of bias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.