Evidence map›Paper›PMID 40521630›Full record

ArticleJournal of the American Heart Association2025

Long-Term Outcomes in Patients With Hemorrhagic Moyamoya Disease Combined With Hypertension After Encephaloduroarteriosynangiosis.

Qingbao Guo, Manli Xie, Huanhuan Ji, Qian-Nan Wang, Xiangyang Bao, Lian Duan

Abstract read
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Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Qingbao GuoDepartment of Neurosurgery XI'AN NO.9 HOSPITAL Xi'an Shaanxi China.ORCID 0000-0001-6538-375X
Manli XieDepartment of Occupational Diseases Xi'an Central Hospital Xi'an Shaanxi China.ORCID 0009-0001-1372-8135
Huanhuan JiDepartment of Neurosurgery The Eighth Medical Centre, Chinese PLA General Hospital Beijing China.
Qian-Nan WangDepartment of Neurosurgery The Eighth Medical Centre, Chinese PLA General Hospital Beijing China.ORCID 0000-0002-6389-2347
Xiangyang BaoDepartment of Neurosurgery The Fifth Medical Centre, Chinese PLA General Hospital Beijing China.ORCID 0000-0003-1204-7386
Lian DuanDepartment of Neurosurgery The First Medical Centre, Chinese PLA General Hospital Beijing China.ORCID 0000-0001-7210-056X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough hypertension is prevalent in adults with moyamoya disease (MMD) and intracranial hemorrhage significantly worsens prognosis, the impact of hypertension on long-term outcomes after encephaloduroarteriosynangiosis in hemorrhagic MMD remains unclear; this retrospective cohort study used propensity score matching to compare outcomes between hypertensive and nonhypertensive patients and preliminarily assess the role of blood pressure management.

methodsAfter propensity score matching, long-term outcomes post- encephaloduroarteriosynangiosis in patients with hemorrhagic MMD with hypertension from January 2010 to December 2018 were analyzed. The clinical and radiological data were collected. Kaplan-Meier curves evaluated the relationship between recurrence-free survival, overall survival (OS), and hypertension. Univariate and multivariate Cox regression assessed independent factors influencing hematoma recurrence-free survival and OS. Subgroup analysis of patients with hemorrhagic MMD with hypertension assessed the impact of different blood management on long-term outcomes.

resultsKaplan-Meier curves showed a significant correlation between hypertension and decreased hematoma recurrence-free survival (

conclusionsThis study highlights significant differences in hematoma recurrence-free survival and OS between patients with hemorrhagic MMD with and without hypertension. A subgroup analysis of those with hypertension showed that optimal blood pressure control notably lowered hematoma recurrence but did not improve OS. For patients with hemorrhagic MMD with hypertension, optimizing blood pressure alone may be insufficient, emphasizing the importance of personalized integrated strategies for this patient subgroup.

Indexed as

Cerebral RevascularizationHypertensionIntracranial HemorrhagesMoyamoya DiseaseAdultBlood PressureFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk FactorsTime FactorsTreatment Outcomeencephaloduroarteriosynangiosishemorrhagic moyamoya diseasehypertensionlong‐term outcomesoptimizing blood pressure management

Identifiers

PMID40521630
PMCPMC12229203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.