Evidence map›Paper›PMID 40521590›Full record

ReviewCurrent ophthalmology reports2025

Emerging Techniques in the Treatment of Conjunctival Melanoma.

Wendy J Li, Nandini Venkateswaran, Michael Antonietti, Sana Qureshi, Anat Galor, Carol L Karp

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current ophthalmology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wendy J Li *Department of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17 thStreet, Miami, FL 33136 USA.
Nandini Venkateswaran *Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA USA.
Michael AntoniettiDepartment of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17 thStreet, Miami, FL 33136 USA.
Sana QureshiMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA USA.
Anat GalorDepartment of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17 thStreet, Miami, FL 33136 USA.
Carol L KarpDepartment of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17 thStreet, Miami, FL 33136 USA.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
BLRD VA I01 BX004893CSRD VA I01 CX002015CSRD VA I01 CX002633NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174RRD VA I21 RX003883
6 · The paper itself

Abstract

Purpose of review: In this article, we summarize the pathogenesis, diagnostic challenges, current management, and emerging therapeutic strategies for conjunctival melanoma (CM). Recent findings: CM is a deadly disease with rising global incidence. Key mutations, including BRAF, NF1, and TERT, play crucial roles in CM pathogenesis and may serve as targets for therapy. Advanced imaging and histopathological analysis have improved early detection and prognostic assessment. Treatment depends on tumor stage and includes surgical excision with adjuvant chemotherapy, radiotherapy, or orbital exenteration in advanced cases. Systemic workup is always indicated. Immune checkpoint inhibitors, successful in cutaneous melanoma, show promise in CM based off early studies, although more research is needed to confirm their benefit. Summary: CM remains a significant clinical challenge and requires a multidisciplinary approach to diagnosis and treatment. Incorporating genetic profiling and targeted therapies is crucial to improving patient outcomes.

Indexed as

BrachytherapyConjunctival melanomaImmunotherapyMelanocytic lesionsPrimary acquired melanosisSurgical excision

Identifiers

PMID40521590
PMCPMC12162382

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.