Evidence map›Paper›PMID 40521458›Full record

ArticleACS omega2025

Identification of Novel Leishmania donovani Nucleoside Hydrolase Inhibitors from Banisteriopsis laevifolia Using Affinity Selection-Mass Spectrometry.

Pamella C O de Oliveira, Pedro R C Medeiros, Bruno C B Marques, Jorge L S Simão, Martin Albino, Vanessa G P Severino, Claudio Sangregorio, Luzineide W Tinoco, Marcela C de Moraes

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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pamella C O de OliveiraBioCrom, Organic Chemistry Department, Chemistry Institute, Fluminense Federal University, 24020-141 Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-4846-0367
Pedro R C MedeirosBioCrom, Organic Chemistry Department, Chemistry Institute, Fluminense Federal University, 24020-141 Niterói, Rio de Janeiro, Brazil.
Bruno C B MarquesLaboratory for Analysis and Development of Enzyme Inhibitors, Natural Products Research Institute, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil.
Jorge L S SimãoInstitute of Chemistry, Federal University of Goiás, Campus Samambaia, Esperança Avenue, 74690-900 Goiânia, Brazil.
Martin AlbinoICCOM-CNR, 50019 Sesto Fiorentino (FI), Italy.ORCID https://orcid.org/0000-0001-7438-0833
Vanessa G P SeverinoInstitute of Chemistry, Federal University of Goiás, Campus Samambaia, Esperança Avenue, 74690-900 Goiânia, Brazil.
Claudio SangregorioICCOM-CNR, 50019 Sesto Fiorentino (FI), Italy.ORCID https://orcid.org/0000-0002-2655-3901
Luzineide W TinocoLaboratory for Analysis and Development of Enzyme Inhibitors, Natural Products Research Institute, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-1299-6242
Marcela C de MoraesBioCrom, Organic Chemistry Department, Chemistry Institute, Fluminense Federal University, 24020-141 Niterói, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-7448-5301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification of enzyme inhibitors from natural sources offers a promising pathway for drug discovery. In this study, affinity selection-mass spectrometry (AS-MS) was employed to screen for inhibitors of Leishmania donovani nucleoside hydrolase (

Identifiers

PMID40521458
PMCPMC12163827

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.