ArticleACS omega2025
Pharmacological Potential of Cafestol, a Bioactive Substance in Coffee, in Preventing Ischemia-Reperfusion-Induced Acute Kidney Injury.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Attenuation of cerebral ischemia-reperfusion induced neurotoxicity by telmisartan, ertugliflozin, and omaveloxolone through Nrf2/HO-1 pathway modulation: In vivo and in silico insights.Toxicology reports · 2025Article
- Therapeutic Modulation of Mitophagy by Cafestol in Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis.Nutrients · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal ischemia-reperfusion (I/R) is the leading cause of acute kidney injury (AKI) and is a relevant complication of kidney transplantation. This work evaluated whether a single dose of cafestol (CAF) prevents I/R-induced AKI. We randomly divided male Wistar rats (180-220 g) into sham-operated groups (CTRL) or I/R surgery groups (I/R), which received either CAF 50 mg/kg or 75 mg/kg orally 2 h before the I/R procedure. During 24 h of reperfusion, rats were placed in metabolic cages for urine collection. The rats were euthanized, blood and urine were stored for renal function analyses, and the kidneys were collected for biochemical and histological studies. The I/R rats developed AKI, as evidenced by kidney damage (space between tubules, glomerular segmentation, and marked collagen accumulation throughout the renal tissue) and a decline in function and Na
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Registered trials
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