Evidence map›Paper›PMID 40521395›Full record

ArticleEJHaem2025

Outcomes for Patients With Myeloid Neoplasms Treated With Chemotherapy Plus Venetoclax After Prior Venetoclax Therapy.

Rafael Madero-Marroquin, Joseph Cannova, Emily Dworkin, Austin Wesevich, Gregory W Roloff, Caner Saygin, Mariam T Nawas, Adam S DuVall, Satyajit Kosuri, Michael J Thirman and 5 more

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rafael Madero-MarroquinSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.ORCID https://orcid.org/0009-0002-9243-2662
Joseph CannovaSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Emily DworkinDepartment of Pharmacy University of Chicago Medicine Chicago Illinois USA.
Austin WesevichSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Gregory W RoloffSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Caner SayginSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Mariam T NawasSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Adam S DuVallSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Satyajit KosuriSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Michael J ThirmanSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Olatoyosi OdenikeSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Wendy StockSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Richard A LarsonSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Michael W DrazerSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.
Anand A PatelSection of Hematology/Oncology Department of Medicine University of Chicago Chicago Illinois USA.ORCID https://orcid.org/0000-0002-0296-8686

Funding

CLINICAL THERAPEUTICST32GM007019 · NIGMS · UNIVERSITY OF CHICAGO · PI Peter Hugh O'Donnell, MARK J RATAIN · 1985 to 2026
$8.7M
NIGMS NIH HHS T32 GM007019
6 · The paper itself

Abstract

Background: Outcomes for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that have progression after treatment with hypomethylating agent (HMA) and venetoclax (VEN) are poor. However, data for chemotherapy and VEN (C+VEN) therapy after prior treatment with HMA+VEN are limited. Methods: We identified 18 patients with AML or MDS/AML who received C+VEN after prior HMA+VEN. Results: Complete remission (CR) or CR with incomplete hematologic recovery (CRi) was achieved in 7 patients (39%) and 6 patients (33%) proceeded to allogeneic hematopoietic stem cell transplantation. Conclusion: This study shows suggests that C+VEN could be a viable option in a subset of patients after HMA+VEN.

Indexed as

acute leukemiaAMLchemotherapyMDSmyeloid leukemia

Identifiers

PMID40521395
PMCPMC12163342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.