ArticleFrontiers in nutrition2025
Higher HEI-2015 score is associated with reduced risk of Parkinson's disease: a nationwide population-based study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A nonlinear association and threshold effect of healthy eating index-2015 with hypertension in US children and adolescents: a cross-sectional analysis of NHANES 1999-2020.Journal of health, population, and nutrition · 2026Article
- Diet-Microbiome Relationships in Prostate-Cancer Survivors with Prior Androgen Deprivation-Therapy Exposure and Previous Exercise Intervention Enrollment.Microorganisms · 2026Article
- Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework.Frontiers in aging neuroscience · 2026Review
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Authors and funding
4 authors.
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Abstract
Background: Recent studies have highlighted the significant role of diet in the development of Parkinson's disease (PD). However, research on the association between diet quality and PD in the general adult population of the United States remains limited. This study aims to assess the relationship between diet quality, measured by the Healthy Eating Index 2015 (HEI-2015) score, and the risk of PD. Methods: Data for this cross-sectional analysis were obtained from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018, which includes a nationally representative sample of US adults. Diet quality was measured using the HEI-2015 score, and weighted multivariable logistic regressions and restricted cubic splines (RCS) were applied to examine the correlation between HEI-2015 and PD. Threshold effects were computed using a two-segment linear regression model. Subgroup and sensitivity analyses, including multiple imputations, unweighted logistic regression, and exclusion of participants with HEI-2015 scores beyond 3 standard deviations (mean ± 3SD), were performed to assess the robustness of the findings. Results: A total of 29,581 US adults were included in the analysis, with 286 participants diagnosed with PD. In the fully adjusted multivariable model, each 10-point increase in the HEI-2015 score was associated with a 17% reduction in the likelihood of PD (odds ratio (OR):0.858,95% confidence interval (CI):0.742-0.992, Conclusion: HEI-2015 is negatively associated with the prevalence of PD. This suggests that modifiable lifestyle factors, particularly diet quality, may play an important role in reducing the risk of PD.
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