Evidence map›Paper›PMID 40521350›Full record

ArticleJournal of virus eradication2025

Dynamic changes in immune cell subsets in blood and lymph node over the course of acute HIV infection.

Supranee Buranapraditkun, Julie L Mitchell, Hiroshi Takata, Eugene Kroon, Suteeraporn Pinyakorn, Nicha Tulmethakaan, Sopark Manasnayakorn, Suthat Chottanapund, Pattarawat Thantiworasit, Peeriya Prueksakaew and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virus eradication, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Supranee BuranapraditkunDivision of Allergy and Clinical Immunology, Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Thai Red Cross Society, Bangkok, 10330, Thailand.
Julie L MitchellU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Hiroshi TakataU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eugene KroonSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Suteeraporn PinyakornU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nicha TulmethakaanSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Sopark ManasnayakornDivision of Allergy and Clinical Immunology, Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Thai Red Cross Society, Bangkok, 10330, Thailand.
Suthat ChottanapundSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Pattarawat ThantiworasitDivision of Allergy and Clinical Immunology, Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Thai Red Cross Society, Bangkok, 10330, Thailand.
Peeriya PrueksakaewSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Nisakorn RatnaratornSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Khunthalee BenjapornpongSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Bessara NuntapinitArmed Forces Research Institute of Medical Sciences in Bangkok, Bangkok, Thailand.
Praphan PhanuphakInstitute of HIV Research and Innovation (IHRI), Bangkok, Thailand.
Carlo P SacdalanSEARCH Research Foundation (SEARCH), Bangkok, Thailand.
Nittaya PhanuphakInstitute of HIV Research and Innovation (IHRI), Bangkok, Thailand.
Kiat RuxrungthamCenter of Excellence in Vaccine Research (Chula VRC); School of Global Health; and Development of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jintanat AnanworanichDepartment of Global Health, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Sandhya VasanU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lydie TrautmannU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate, cellular and humoral immunity in acute HIV infection (AHI) play crucial roles in dictating immunological and pathological outcomes. However, understanding immune cell dynamics in different compartments during AHI is limited. In this study, we characterized immune cells from matched blood and lymph node samples in the RV254 Thai AHI cohort, the RV304 Thai chronic HIV infection cohort, and HIV-negative individuals, using flow cytometry. Our results showed a significant loss of the CD4:CD8 ratio in both PBMCs and LNMCs during AHI. Similarly, we observed increased immune activation of CD4

Indexed as

Acute HIV infection (AHI)BloodImmune cell subsetsLymph nodes

Identifiers

PMID40521350
PMCPMC12164039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.