Evidence map›Paper›PMID 40521345›Full record

ArticleGynecologic oncology reports2025

Clinical and fertility outcomes in lynch syndrome patients with endometrial carcinoma or endometrial Intraepthelial neoplasia treated with fertility sparing management.

Hadley W Reid, Alexandria N Young, Sophia H Yin, Isabela Covelli Velez, Mary Kathryn Abel, David L Kolin, Elizabeth S Ginsburg, Matthew B Yurgelun, Colleen Feltmate, Jessica D St Laurent

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Updates and evolving care paradigms for pre-menopausal patients with endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hadley W ReidDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
Alexandria N YoungDepartment of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
Sophia H YinDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
Isabela Covelli VelezDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
Mary Kathryn AbelDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
David L KolinDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth S GinsburgDivision of Reproductive Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
Matthew B YurgelunDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Colleen FeltmateDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.
Jessica D St LaurentDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Provide evidence on fertility-sparing treatment for patients with Lynch Syndrome (LS) and early-stage low grade endometrioid endometrial cancer (EC) or endometrial intraepithelial neoplasia (EIN). Methods: We conducted a retrospective chart review of patients with EC or EIN, LS pathogenic germline variant, and treatment with progestin therapy without upfront hysterectomy due to desire to preserve fertility. Demographic, clinical, and reproductive variables were collected. Results: Of the 273 patients who met criteria for LS with EIN (38) or EC (235) there were seven patients, three with an initial diagnosis of EIN and four with an initial diagnosis of EC who underwent fertility sparing treatment. The median age was 36 (range 31-44) at diagnosis with the following mutations Conclusion: Fertility sparing management for LS patients with an EIN or EC diagnosis is uncommon. Progesterone response rates appear to be lower than those in sporadic cases, though similar clinical and histologic factors (age, BMI, and p53 expression pattern) may predict disease regression and fertility outcomes. A larger sample and standardized treatment paradigm are needed to provide more evidence on fertility sparing management for LS patients.

Indexed as

Endometrial cancerEndometrial intraepithelial neoplasiaLynch syndromeOncofertility

Identifiers

PMID40521345
PMCPMC12163398

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.