Evidence map›Paper›PMID 40521275›Full record

ArticleIDCases2025

Whole-genome sequencing confirms

Sheridan J C Baker, Laura K Erdman, Donald Brody Duncan, Tania Cellucci, Candy Rutherford, Marek Smieja, Cheryl Main, Jeffrey M Pernica, Andrew G McArthur

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheridan J C BakerDepartment of Biochemistry & Biochemical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Laura K ErdmanDivision of Pediatric Infectious Disease, McMaster Children's Hospital, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Donald Brody DuncanDepartment of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Tania CellucciDivision of Pediatric Rheumatology, McMaster Children's Hospital, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Candy RutherfordHamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, 50 Charlton Ave E, Hamilton, Ontario L8N 4A6, Canada.
Marek SmiejaMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Cheryl MainDepartment of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Jeffrey M PernicaMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Andrew G McArthurDepartment of Biochemistry & Biochemical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Differentiating severe systemic inflammatory syndromes from sepsis can be challenging. The diagnostic process may be further complicated by concurrent infection and hyperinflammation, with important management implications. We report a child with suspected multisystem inflammatory syndrome in children, who was unexpectedly diagnosed with Case presentation: A previously healthy 6-year-old boy acutely presented with fever, vomiting, diarrhea, fluid-refractory shock, cardiac dysfunction, biochemical inflammation, and coagulopathy. He fulfilled diagnostic criteria for multisystem inflammatory syndrome in children, including SARS-CoV-2 exposure 8 weeks prior. He received both antibiotics and pulsed intravenous methylprednisolone, with rapid improvement. Stool molecular testing using a lab-developed multiplex qPCR assay revealed Conclusions: This case underscores the importance of systematic microbiological workup in suspected systemic inflammatory syndromes, to identify infections that are treatable and of public health relevance. Given the rarity of

Indexed as

Case reportMultisystem inflammatory syndrome in childrenShigellaShockWhole-genome sequencing

Identifiers

PMID40521275
PMCPMC12166990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.