Evidence map›Paper›PMID 40521270›Full record

ArticleWorld journal of gastroenterology2025

Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation.

Xiao-Mei Wang, Ze Dai, Dai-Jun Lu, Chao-Qun Bao, Nai-Bin Yang, Yu-Ping Zhou

Abstract read
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In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao-Mei WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Ze DaiHealth Science Center, Ningbo University, Ningbo 315211, Zhejiang Province, China.
Dai-Jun LuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Chao-Qun BaoDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Nai-Bin YangDepartment of Hepatology, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.
Yu-Ping ZhouDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Ningbo University, Ningbo 315020, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a prominent and pervasive global health challenge. Bicuculline (BIC), which is a key active component of the anti-MASLD prescription "Eight Zhes Decoction", has been preliminarily shown by our research team to have significant potential in treating MASLD.

aimTo determine BIC's efficacy in treating MASLD by regulating lipid metabolism and suppressing hepatic inflammation

methodsThis study explored the potential of BIC in preventing and treating MASLD using zebrafish, cellular (HepG2 and AML12), and mouse models.

resultsOur results indicate that BIC significantly reduces lipid accumulation and inflammation both

conclusionThis study is the first to demonstrate that BIC specifically alleviates lipid accumulation and hepatic steatosis in MASLD models

Indexed as

BicucullineFatty LiverLipid MetabolismNF-kappa BAnimalsDisease Models, AnimalHep G2 CellsHumansLiverMaleMiceMice, Inbred C57BLSignal TransductionZebrafishBicucullineNF-kappa BBicucullineHepatic steatosisLipid accumulationLipid metabolismMetabolic dysfunction-associated steatotic liver diseaseNuclear factor-kappa B

Identifiers

PMID40521270
PMCPMC12159988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.