Evidence map›Paper›PMID 40521267›Full record

ArticleWorld journal of gastroenterology2025

Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study.

Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan-Ping WuDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Jia-Xuan ZhouDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Hong-Bo WuDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Di-Ping WuDepartment of Cyberspace Security, Beijing Electronic Science and Technology Institute, Beijing 100000, China.
Ling-Zhi QinDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Bin QinDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Xiao-Yu XuDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Saleh Abdulaziz Abdulgani YehyaDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China.
Yan ChengDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China. 15609264849@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReflux hypersensitivity (RH) constitutes roughly 14% of patients with heartburn and 34% of those with refractory heartburn, yet it is inadequately comprehended.

aimTo investigate the clinical characteristics and risk factors associated with RH.

methodsWe conducted a retrospective analysis of 109 patients with RH and 384 healthy controls from three medical centers between January 2022 and December 2023. Comprehensive data encompassing symptoms, motility, impedance-pH monitoring, and psychological evaluations were collected.

resultsRH patients encountered a greater frequency of weakly acidic reflux (WAR) events compared to acidic reflux or nonacidic reflux (NAR) events. Upright reflux time (1.22%) exceeds supine reflux time (0.54%) (

conclusionWAR and NAR are pivotal in RH. Patients with increased NAR are more likely to experience extraesophageal symptoms. Age, hiatal hernia, and anxiety are significant independent risk factors for RH.

Indexed as

Gastroesophageal RefluxHeartburnHernia, HiatalAdultAgedAge FactorsAnxietyCase-Control StudiesEsophageal pH MonitoringFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSex FactorsClinical characteristicsFunctional esophageal diseaseGastroesophageal reflux diseaseReflux hypersensitivityRisk factors

Identifiers

PMID40521267
PMCPMC12159985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.