Evidence map›Paper›PMID 40521198›Full record

ReviewTheranostics2025

Piezo-catalytic immunotherapy: mechanisms and feasibility in cancer treatment.

Zhiguang Chen, Liang Sang, Donglin Bian, Yanjun Liu, Zhiqun Bai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiguang ChenDepartment of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.
Liang SangDepartment of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.
Donglin BianDepartment of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.
Yanjun LiuDepartment of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.
Zhiqun BaiDepartment of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decade, immunotherapy has revolutionized the clinical management of numerous cancer types. However, only a subset of patients derives long-term durable tumor control from it. Intriguingly, several emerging therapeutic strategies harnessing reactive oxygen species (ROS)-mediated immunogenic cell death (ICD) hold promise for enabling precision immunotherapy in cancer, with sonodynamic therapy emerging as a notable example. The utilization of piezoelectric materials as sonosensitizers can effectively enhance ROS production, thereby augmenting the efficacy of ICD-induced immunotherapy. Additionally, electrical stimulation generated by the piezoelectric effect can further induce immune response activation and necroptosis, achieving a synergistic effect in piezo-catalytic immunotherapy. Herein, we will systematically review the pathways and potential mechanisms underlying piezo-catalytic immunotherapy, offering novel insights for the exploration of cancer immunotherapy strategies.

Indexed as

ImmunotherapyNeoplasmsUltrasonic TherapyAnimalsHumansImmunogenic Cell DeathReactive Oxygen SpeciesReactive Oxygen SpeciesImmunotherapyPiezoelectric effectSonodynamic therapySono-piezo dynamic therapyTumor immune microenvironment

Identifiers

PMID40521198
PMCPMC12159825

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.