Evidence map›Paper›PMID 40521197›Full record

ArticleTheranostics2025

BCAA catabolism targeted therapy for heart failure with preserved ejection fraction.

Meng Wang, Zhao Liu, Shuxun Ren, Jinyun Zhu, Norihiko Morisawa, Geok Lin Chua, Xuewen Zhang, Yun Ka Wong, Liping Su, Ming Xiang Wong and 9 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Biomarkers of Cardiac Metabolic Flexibility in Health, HFrEF and HFpEF.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Meng WangSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Zhao LiuSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Shuxun RenSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Jinyun ZhuSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Norihiko MorisawaSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Geok Lin ChuaSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Xuewen ZhangSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Yun Ka WongSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Liping SuNational Heart Center of Singapore, Singapore.
Ming Xiang WongSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Jieping YangDepartment of Medicine, University of California, Los Angeles, CA, USA.
Marc Titze JensSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Zhaoping LiDepartment of Medicine, University of California, Los Angeles, CA, USA.
Haipeng SunNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
Yibin WangSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.
Christoph D RaulDepartment of Genetics and Computational Medicine Program, University of North Carolina at Chapel Hill, NC, USA.
Sanjiv J ShahDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, IL, USA.
Chen GaoDepartment of Pharmacology and Systems Physiology, University of Cincinnati, OH, USA.
Yunxia LiuSignature Research Programme in Cardiovascular and Metabolic Disorders, DukeNUS Medical School, Singapore.

Funding

Elucidating the Role of Multinuclearity in Healthy and Diseased Mammalian CardiomyocytesR01HL162636 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christoph Daniel Rau · 2023 to 2026
$1.9M
Discovery of Novel Epigenetic Regulators of Heart Failure in a Panel of MiceR00HL138301 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAU, CHRISTOPH DANIEL · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL138301NHLBI NIH HHS R01 HL162636
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acids, Branched-ChainHeart FailureStroke VolumeAgedAnimalsDiet, High-FatDisease Models, AnimalFemaleHumansMaleMetabolomicsMiceMice, Inbred C57BLNG-Nitroarginine Methyl EsterProtein Kinases(3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinaseAmino Acids, Branched-ChainNG-Nitroarginine Methyl EsterProtein KinasesBCAA metabolismBT2heart failureHFpEFinsulin resistance

Identifiers

PMID40521197
PMCPMC12159833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.