Evidence map›Paper›PMID 40521192›Full record

ArticleTheranostics2025

GPA33-pretargeted radioimmunotherapy with mono- and bivalent DOTA-based Lu-177-labeled radiohaptens in a mouse orthotopic liver xenograft model of metastatic human colorectal cancer.

Alexandre B Le Roux, Edward K Fung, Sang Gyu Lee, Sebastien Monette, Hong Xu, Hong-Fen Guo, Guangbin Yang, Ouathek Ouerfelli, Achim Jungbluth, Heiko Schöder and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexandre B Le RouxDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Edward K FungDepartment of Radiology, Weill Cornell Medicine, New York, NY.
Sang Gyu LeeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Sebastien MonetteLaboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and Rockefeller University, New York, NY.
Hong XuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.
Hong-Fen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.
Guangbin YangOrganic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.
Ouathek OuerfelliOrganic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.
Achim JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.
Sarah M ChealDepartment of Radiology, Weill Cornell Medicine, New York, NY.
Darren R VeachDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsLutetiumRadioimmunotherapyRadioisotopesRadiopharmaceuticalsAnimalsAntibodies, BispecificCell Line, TumorFemaleHeterocyclic Compounds, 1-RingHumansMembrane GlycoproteinsMiceMice, NudeTissue Distribution1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAntibodies, BispecificGPA33 protein, humanHeterocyclic Compounds, 1-RingLutetiumLutetium-177Membrane GlycoproteinsRadioisotopesRadiopharmaceuticalscolorectal cancer hepatic metastasisLu-177multivalent radiohaptenpretargeted radioimmunotherapytheranostics

Identifiers

PMID40521192
PMCPMC12159840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.