Evidence map›Paper›PMID 40521184›Full record

ArticleTheranostics2025

SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.

Xinyu Wang, Gaowei Hu, Yupeng Shao, Zhongwei Dong, Lina Liu, Yixuan Wang, Yaxi Xie, Nuoya Yu, Caixia Zhu, Fang Wei and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinyu WangMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Gaowei HuMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Yupeng ShaoMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Zhongwei DongMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Lina LiuMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Yixuan WangExpert Workstation, Baoji Central Hospital, Baoji 721008, P. R. China.
Yaxi XieMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Nuoya YuMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Caixia ZhuMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Fang WeiShengYushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic & Development Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Yuping JiaShandong Academy of Pharmaceutical Sciences, Jinan, 250100, P. R. China.
Yuyan WangMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
Qiliang CaiMOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antiviral AgentsCOVID-19COVID-19 Drug TreatmentSARS-CoV-2Spike Glycoprotein, CoronavirusSumoylationAnimalsCell LineDisease Models, AnimalHEK293 CellsHumansMiceMice, TransgenicSUMO-1 ProteinAntiviral AgentsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2SUMO-1 ProteinAntiviral peptidesSARS-CoV-2Spike proteinSUMOylation

Identifiers

PMID40521184
PMCPMC12160036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.