Evidence map›Paper›PMID 40521183›Full record

ArticleTheranostics2025

Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis.

Praveen Gajawada, Stefan Günther, Andreas Rolf, Jamal Nabhanizadeh, Rajkumar Savai, Yeong-Hoon Choi, Manfred Richter

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Praveen GajawadaDepartment of Cardiac Surgery, Kerckhoff Heart Center, Benekestr. 2-8, Bad Nauheim 61231, Germany.
Stefan GüntherBioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.
Andreas RolfDepartment of Cardiology, Kerckhoff Heart and Lung Center, Benekestrasse 2-8, Bad Nauheim 61231, Germany.
Jamal NabhanizadehMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, 61231, Germany.
Rajkumar SavaiMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, 61231, Germany.
Yeong-Hoon ChoiDepartment of Cardiac Surgery, Kerckhoff Heart Center, Benekestr. 2-8, Bad Nauheim 61231, Germany.
Manfred RichterDepartment of Cardiac Surgery, Kerckhoff Heart Center, Benekestr. 2-8, Bad Nauheim 61231, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac sarcoidosis (CS) is an inflammatory condition characterized by the accumulation and clustering of immune cells, primarily macrophages, leading to granuloma formation. Despite its clinical significance, CS remains relatively understudied, particularly concerning the molecular mechanisms driving fibrosis and disease progression. To explore potential therapeutic targets, we aimed to characterize the transcriptomic landscape of CS granulomas.

Indexed as

CardiomyopathiesGranulomaSarcoidosisTranscriptomeAgedChitinase-3-Like Protein 1FemaleGene Expression ProfilingHumansMacrophagesMaleMiddle AgedMyocardiumCHI3L1 protein, humanChitinase-3-Like Protein 1chemoattractionchitinase-3-like protein 1chitotriosidase-1colony stimulating factor 1 receptorhuman leukocyte antigenimmune cellsinflammationinterleukin-4 receptorinterleukin-7 receptorm2 macrophage

Identifiers

PMID40521183
PMCPMC12159750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.