Observational studyFrontiers in cellular and infection microbiology2025
Impact of overlapping fungal infection on the occurrence and prognosis of carbapenem-resistant gram-negative bacilli infection.
Observational study in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: The global threat of carbapenem-resistant gram-negative bacteria (CRGNB) infection is compounded by concurrent fungal infections, which present additional clinical challenges. This study aims to elucidate the impact of fungal infection on the occurrence and prognosis of CRGNB infection. Methods: We conducted a retrospective, single-center, observational cohort study of 2,273 patients with CRGNB and/or fungal infection from January 2018 to April 2023. Binary logistic regression analysis and multivariable Cox proportional hazards regression model were used to determine risk factors for the occurrence and prognosis of patients with CRGNB or fungal infections. Survival analysis was performed to investigate the impact of fungal co-infection on mortality of total GRGNB and bacterial subclasses infections. Results: Fungal infection was a independent risk factor for CRGNB infection (OR=1.381, Conclusions: In the current study, it was discovered that fungal infections preceded GRGNB infections and might contribute to the development of antibiotic resistance in some gram-negative bacteria, which ultimately leads to more severe clinical outcomes.
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