ArticleDrug design, development and therapy2025
Impact of Fungal Co-Infection on Teicoplanin Plasma Trough Concentration in Critically Ill Adults: A Novel Consideration for Dose Adjustment.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Machine learning-based prediction model for teicoplanin plasma concentrations in adults with liver disease using real-world data.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The pathophysiology and disease status of critically ill patients have a significant impact on the pharmacokinetics/pharmacodynamics (PK/PD) of antimicrobial agents. However, the effect of fungal co-infection on the plasma trough concentration (C Materials and Methods: A retrospective cohort study was carried out. Clinical data of patients admitted to the intensive care unit and receiving teicoplanin therapeutic drug monitoring were collected. Multiple linear stepwise regression analysis and binary logistic regression analysis were used to identify the factors influencing teicoplanin C Results: A total of 404 teicoplanin C Conclusion: For critically ill patients with fungal co-infections, the teicoplanin dose should be decreased, or at least not increased. This is essential for reducing the potential risk of toxicity and customizing dosing strategies to meet individual patient needs. A large-scale, multi-center, prospective study is necessary to confirm the findings related to this dosing approach.
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