Evidence map›Paper›PMID 40520967›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Blood-brain barrier permeability in relation to disease severity and timing of multiple sclerosis diagnosis in optic neuritis.

Moschoula Passali, Maria Højberg Knudsen, Knud Josefsen, Julie Christine Antvorskov, Amalie Monberg Hindsholm, Ulrich Lindberg, Jette Lautrup Frederiksen, Henrik Bo Wiberg Larsson, Stig Præstekjær Cramer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Moschoula PassaliOptic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID https://orcid.org/0000-0003-2759-7903
Maria Højberg KnudsenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-0432-1488
Knud JosefsenThe Bartholin Institute, Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Julie Christine AntvorskovThe Bartholin Institute, Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Amalie Monberg HindsholmFunctional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID https://orcid.org/0000-0002-0049-0842
Ulrich LindbergFunctional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID https://orcid.org/0000-0002-0004-6354
Jette Lautrup FrederiksenOptic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID https://orcid.org/0000-0003-1661-7438
Henrik Bo Wiberg LarssonDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1348-7749
Stig Præstekjær CramerFunctional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID https://orcid.org/0000-0003-2959-2161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dynamic contrast-enhanced magnetic resonance imaging is a promising biomarker allowing for in vivo quantification of blood-brain barrier permeability. Objectives: To explore the relationship between blood-brain barrier permeability, optic neuritis disease severity, and multiple sclerosis conversion in optic neuritis. Methods: Gjedde-Patlak models from dynamic contrast-enhanced magnetic resonance imaging were used to estimate blood-brain barrier permeability ( Results: Normal-appearing white matter Conclusions: Normal-appearing white matter

Indexed as

biomarkersblood–brain barrierDynamic contrast-enhanced MRImultiple sclerosisneuroinflammationoptic neuritis

Identifiers

PMID40520967
PMCPMC12163281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.