Evidence map›Paper›PMID 40520948›Full record

ReviewFrontiers in artificial intelligence2025

Can artificial intelligence improve the diagnosis and prognosis of disorders of consciousness? A scoping review.

Mirjam Bonanno, Davide Cardile, Piergiuseppe Liuzzi, Antonio Celesti, Giuseppe Micali, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

Abstract readReview
In one paragraph

Review in Frontiers in artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mirjam Bonanno *IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Davide Cardile *IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Piergiuseppe LiuzziIRCCS Fondazione Don Carlo Gnocchi ONLUS, Firenze, Italy.
Antonio CelestiDepartment of Mathematics and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, Messina, Italy.
Giuseppe MicaliIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Francesco CoralloIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Francesco TomaiuoloDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Artificial intelligence (AI), in the form of machine learning (ML) or deep learning (DL) models, can aid clinicians in the diagnostic process and/or in the prognosis of critically medical conditions, as for patients with a disorder of consciousness (DoC), in which both aspects are particularly challenging. DoC is a category of neurological impairments that are mainly caused by severe acquired brain injury, like ischemic or hemorrhagic strokes or traumatic injuries. The aim of this scoping review is to map the literature on the role of ML and DL in the field of diagnosis and prognosis of DoCs. Materials and methods: A scoping search, started from 3rd October 2024, was conducted for all peer-reviewed articles published from 2000 to 2024, using the following databases: PubMed, Embase, Scopus and Cochrane Library. Results: We found a total of 49,417 articles. After duplicate removal and title/abstract screening, 613 articles met the inclusion criteria, but 592 articles were excluded after full-text review. Therefore, only 21 studies involving DoC subjects were included in the review synthesis. Conclusion: Advancing AI in the field of DoC requires standardized data protocols and consideration of demographic variations. AI could enhance diagnosis, prognosis, and differentiation between states like unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Additionally, AI-based applications personalize rehabilitation by identifying key recovery factors, optimizing patient outcomes.

Indexed as

artificial intelligencedeep learningdiagnosisdisorder of consciousnessinterpretabilitymachine learningneurorehabilitationprognosis

Identifiers

PMID40520948
PMCPMC12162576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.