ArticleFrontiers in cardiovascular medicine2025
Effect of exercise training on cardiac function and glucose metabolism in the ischemic border zone: insights from multi-modal imaging techniques.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: This study aimed to evaluate the impact of early exercise following acute myocardial infarction (AMI) on cardiac function, myocardial remodeling, glucose metabolism, and its molecular changes using cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET). Methods and results: Thirteen rats (MI-exercise, MIE) underwent an 8-week treadmill exercise training initiated 1 week after AMI. Longitudinal assessments were conducted using 7T CMR and Conclusions: Early exercise post-AMI, as assessed by CMR and PET imaging, significantly improved cardiac function, reduced myocardial remodeling, and enhanced glucose metabolism. These benefits were mediated through the upregulation of GLUT4 and PFKFB3 expression, underscoring the potential of exercise as a therapeutic strategy in post-AMI management.
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