ArticleFrontiers in cardiovascular medicine2025
Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery-is there an association?
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
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Authors and funding
11 authors.
Funding
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Abstract
Background: Patients with congenital heart disease (CHD) who are operated on after birth are at risk for neurodevelopmental (ND) impairment. Before birth, altered fetal hemodynamics due to the CHD may lead to reduced cerebral perfusion and oxygen supply. The placenta as a critical organ may enhance this pathology. Methods: Neonates with operated complex CHD were included. We scored the placental pathology and analyzed structural and volumetric brain changes of perioperative brain MRI and ND outcome data using the Bayley III at 1 year of age. Results: A total of 45 (13 female) patients with D-transposition of the great arteries ( Conclusions: Abnormal placental findings in patients with complex CHD are associated with smaller brain volumes, underlining the impact of placental function on brain development as a cofactor in patients with CHD.
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