ArticleGastro hep advances2025
Adverse Childhood Experiences Are Associated With an Increased Risk of Dyspepsia in Patients Undergoing Upper Endoscopy.
Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Subtype Comparison of Psychosocial Associations With Quality of Life in Functional Dyspepsia.Psychiatry investigation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background and Aims: Stress is a risk factor for dyspepsia; however, neither the type nor timing of stress exposures across the lifespan in this syndrome are well understood. We aimed to understand the association between both adverse childhood experiences (ACEs) and experience of current life stress with dyspepsia by collecting and analyzing survey data from a racially diverse cohort of adult research patients presenting for upper endoscopy (esophagogastroduodenoscopy). Methods: The Gastric Immune Response and Cancer Interception study is a cohort study that enrolled adults scheduled for esophagogastroduodenoscopy at an academic center and administered a detailed survey, including questions on ACEs, current adult stress, and dyspepsia symptoms. Endoscopy and pathology results were abstracted from the medical record. Multivariable logistic regression was performed to determine the association between stress exposures and dyspepsia outcomes. Results: Among 187 participants who completed dyspepsia questions, exposure to 2 or more ACEs compared to none was associated with over a two-and-a-half-fold increase in the odds of self-reported dyspepsia (age-adjusted odds ratio = 2.56; 95% confidence interval: 1.24-5.25), with the strongest association with ACE measures of childhood abuse. ACEs were also associated with epigastric pain syndrome ( Conclusion: In patients undergoing endoscopy, exposure to multiple ACEs were associated with dyspepsia. These findings suggest that assessing ACEs in patients with dyspepsia could help provide additional insights into factors associated with dyspepsia symptoms beyond
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.