ArticleGastro hep advances2025
Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease.
Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The OMMGut microbes · 2026Review
- Artemisia argyi-enriched fermented soybean meal alleviates ETEC K88-induced intestinal injury in mice in association with gut microbiota remodeling and purine metabolic alterations.BMC veterinary research · 2026Article
- Comparative metagenomic characterization of gut microbiota and antibiotic resistome in multi-facility SPF mice.BMC microbiology · 2026Article
- Macrophage Metabolic Reprogramming in Inflammatory Bowel Diseases: From Pathogenesis to Therapy.Journal of inflammation research · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: The mechanism for increased infertility and adverse pregnancy outcomes in women with active inflammatory bowel disease is unknown. We aimed to create a murine model of chronic gut inflammation to study the pathogenesis of reproductive outcomes in inflammatory bowel disease. Methods: Chronic intestinal inflammation was induced with dextran sodium sulfate (DSS) in specific-pathogen-free (SPF) female mice. SPF mice not treated with DSS served as controls. Daily estrous cycle monitoring was performed. Age-matched groups were cohabitated with SPF males for mating purposes. Pup weights, litter sizes, reproductive hormone serologies, peripheral and mucosal immune changes, and 16S rRNA gene taxonomic profiling of the fecal microbiome were measured and characterized. Results: DSS treatment led to weight loss, increased disease activity index scores, and reduced colon lengths. Compared to SPF controls, DSS mice spent less time in the estrus phase of the reproductive cycle ( Conclusion: Chronic bowel inflammation induces gut dysbiosis and likely contributes to adverse reproductive outcomes through endocrine imbalances. Further investigation with human studies is needed.
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