Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies.

Guang Yang, Wenqing Xie, Hengzhen Li, Wenhao Lu, Ying Liang, Yusheng Li, Yaping Wang, Wenfeng Xiao

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Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

TNFRSF10B Implicated in Osteoarthritis Protection via the Alpha-Tocopherol-to-Sulfate Ratio: A Multiomics and Mendelian Randomization Study.International journal of molecular sciences · 2026
Article
Linoleic acid accelerates osteoarthritis progression in male rats by targeting iron-sulfur clusters to drive ferroptosis in chondrocytes.Nature communications · 2026
Article
The emerging role of lactate in skeletal homeostasis and disorders: Integrated mechanisms and translational opportunities.Journal of orthopaedic translation · 2026
Review
Metabolic pathways linking air pollution to osteoarthritis: Insights from a prospective cohort.PloS one · 2026
Article

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5 · Who and what money

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8 authors.

Guang YangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Wenqing XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Hengzhen LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Wenhao LuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Ying LiangMolecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410008, Hunan, China.

Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Yaping WangTeaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.

Wenfeng XiaoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causal impact of blood metabolites on OA has yet to be definitively established, further studies are needed to explore the specific roles of metabolites in OA. This is a genetic correlation and two-sample bidirectional mendelian randomization study. GWAS summary data of metabolites and OA were extracted from large-scale GWAS study based on Europeans and Asians. LDSC was conducted to estimate the genetic correlations between 233 circulating metabolites and 11 OA phenotypes, MR was then performed to explore the casual association. 41.20% of the metabolic traits showed genetic correlation with All OA, 15.88% with Knee/Hip OA, 51.50% with Knee OA, and 52.79% with Spine OA. No significant genetic correlations were detected between the metabolic traits and other OA phenotypes. Lactate levels was associated with increased odds of All OA (OR: 1.1558, P<0.001), Hip OA (OR: 1.1446, P=0.004), Knee/Hip OA (OR: 1.1820, P<0.001), Knee OA (OR: 1.1375, P=0.001), Spine OA (OR: 1.3179, P<0.001), THR (OR: 1.5290, P<0.001), and TJR (OR: 1.2827, P<0.001), except for Thumb OA (OR: 0.9429, P<0.001). Ratio of conjugated linoleic acid to total fatty acids was associated 6 OA phenotypes: Hip OA (OR: 0.9522, P=0.035), Knee/Hip OA (OR: 1.0890, P<0.001), Knee OA (OR: 1.1429, P<0.001), THR (OR: 1.3800, P<0.001), TJR (OR: 1.3102, P<0.001), and TKR (OR: 1.2555, P<0.001). Glycerol levels exhibited significant MR associations with four OA phenotypes: Finger OA (OR: 0.6669, P<0.001), Hand OA (OR: 0.8682, P=0.011), Hip OA (OR: 0.9395, P<0.001), and Knee OA (OR: 1.1409, P=0.036). This study underscores genetic and causal connections between specific metabolites and OA. These findings could inform future therapeutic metabolic pathways involved in OA.

Indexed as

OsteoarthritisAsian PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisOsteoarthritis, KneePhenotypePolymorphism, Single NucleotideWhite PeopleCirculating metabolitesGenetic CorrelationLDSCMROA

Identifiers

PMID40520891

DOI10.7150/ijms.111848

PMCPMC12163415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.