ArticleAmerican journal of cancer research2025
GTSF1 promotes stemness in uterine carcinosarcoma through CCL1-mediated M1 macrophage aggregation.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Uterine carcinosarcoma (UCS), a high-grade endometrial carcinoma, is a rare but increasingly prevalent malignant gynecologic neoplasm, now accounting for over 5% of endometrial cancers and associated with a characteristically poor prognosis. In this study, we demonstrate that elevated expression of GTSF1 is significantly correlated with reduced disease-free survival (DFS) in UCS patients and promotes enhanced invasive, migratory, and stem-like phenotypes in tumor cells. Mechanistically, we show that GTSF1 drives tumor progression via activation of CCL1, which induces chemotaxis of M1 macrophages toward malignant cells and subsequent IL-6 secretion, thereby amplifying cancer stemness. Multiplex immunohistochemical analysis revealed spatial co-localization and positive correlations among GTSF1, CCL1, and M1 macrophage infiltration in UCS tissue specimens.
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