ReviewAmerican journal of cancer research2025
Paraspeckle Component 1: a multifunctional RNA binding protein.
Review in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Programmable and Switchable RNA Scaffolds for Synthetic Condensate Engineering in Mammalian Cells.bioRxiv : the preprint server for biology · 2026Article
- Labeling of Long Noncoding RNAs to Study Virus-Induced Nuclear Aggregates.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting.Expert opinion on therapeutic targets · 2026Article
- Alternative splicing immune signature for detecting HBV-related hepatocellular carcinoma in peripheral blood mononuclear cells.Biochemistry and biophysics reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraspeckle Component 1 (PSPC1), a Drosophila behavior/human splicing (DBHS) protein family member, represents a pivotal component within paraspeckles. It exerts indispensable functions across a wide array of biological processes, encompassing gene expression, the DNA damage response, the regulation of circadian rhythms, spermatogenesis, cell fate determination, and cancer metastasis. Notably, PSPC1 exhibits overexpression in several types of cancer, including hepatocellular carcinoma, lung cancer, and breast cancer, where it actively contributes to tumorigenesis. This overexpression phenomenon implies that PSPC1 holds the potential to serve as both a biomarker and a therapeutic target for these malignancies. Consequently, a substantial amount of research has been conducted to explore its structure, functions, and role in cancer development and progression. This review article aims to comprehensively summarize the current findings regarding PSPC1.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.