Evidence map›Paper›PMID 40520779›Full record

ArticleFrontiers in medicine2025

Possible protective role of the absence of Hyrtl's anastomosis in monochorionic pregnancy: exploratory case series.

Ziling Liu, Jie Ruan

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ziling LiuKey Laboratory of Birth Defects and Related Diseases in Women and Children, Department of Obstetrics and Gynecology, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China.
Jie RuanKey Laboratory of Birth Defects and Related Diseases in Women and Children, Department of Obstetrics and Gynecology, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Hyrtl's anastomosis, an intra-arterial shunt, serves a protective function in singleton placentas. Our team previously documented a case of a monochorionic (MC) twin placenta lacking Hyrtl's anastomosis. However, research on the impact of absent Hyrtl's anastomosis in twin placentas remains limited. Methods: In the present study, we perfused over 70 cases of MC placentas and identified three additional cases exhibiting the same characteristics. Results: The absence of Hyrtl's anastomosis was found to be present in two cases with severe placental territory discordance and one case of a MC triamniotic pregnancy with reversed arterial perfusion sequence, all of which resulted in uneventful pregnancy courses. Conclusion: The absence of Hyrtl's anastomosis appears to have a protective effect in MC placentas, contrary to its effect in singleton placentas.

Indexed as

Hyrtl’s anastomosismonochorionic pregnancyplacental territory discordancepump fetusselective fetal growth restriction

Identifiers

PMID40520779
PMCPMC12162271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.