ArticleAnesthesia and critical care (Houston, Tex.)2025
High and Low Dose Ketamine in Post-Traumatic Stress Disorder.
Article in Anesthesia and critical care (Houston, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Timely Surgical Approaches for Pediatric Epilepsy Resistant to Medication.Journal of surgery and research · 2026Article
- Posttraumatic stress disorder from early childhood to late adolescence: a resilience-oriented approach to prevention, diagnosis, and clinical management.Discover mental health · 2026Review
- Anesthetic-Induced Developmental Neurotoxicity: Cognitive Sequelae of Early Exposure.Anesthesia and critical care (Houston, Tex.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ketamine has unique properties making it a desirable drug to induce general anesthesia during surgery. However, it is typically reserved for children and adolescent patients due to its side effects in adults, including vivid dreams, hallucinations, and confusional states that may be pleasant or distressing. These symptoms may affect patients with post-traumatic stress disorder (PTSD). PTSD is a trauma-related psychological disorder that is mainly characterized by intrusive thoughts, hypervigilance, and re-experiencing of the trauma event. Most of current research focuses on the use of sub-anesthetic doses of ketamine as a treatment for PTSD. Limited information is known about high-dose ketamine use during general anesthesia and the impact this has on patients who suffer from PTSD. A literature review investigating the effects of anesthetic doses of ketamine on PTSD was conducted for this article. Findings suggest that ketamine has dose-related effects on the severity of PTSD. Specifically, low-dose ketamine has the potential as a therapeutic agent in the treatment of PTSD, while high-dose ketamine may cause worsening of PTSD symptoms. This could occur through the increase in psychomimetic symptoms, decrease in plasticity and metaplasticity, and modulation of fear memory systems experienced with anesthetic doses of ketamine. Currently, there are no published research articles directly measuring the effects of high-dose ketamine on PTSD. Further investigation is warranted to understand if anesthetic doses of ketamine worsen PTSD symptoms. This is important because it can help guide the management approach of an anesthesiologist to safely providing anesthesia to PTSD patients.
Indexed as
Identifiers
40520767PMC12165460What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.