ArticleJournal of orthopaedic case reports2025
A Novel Seven-Day Abbreviated Two-Stage Exchange Arthroplasty with Intra-Articular Antibiotic Irrigation for Chronic Periprosthetic Joint Infection of the Knee: A Case Report.
Article in Journal of orthopaedic case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Clinical and psychosocial impact of limited mobility during the interstage period of two-stage revision arthroplasty for prosthetic joint infection: a state-of-the-art review.Journal of orthopaedic surgery and research · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The current standard for treating chronic periprosthetic joint infection (PJI) in North America, a two-stage exchange arthroplasty, has success rates of 65-90% but involves prolonged interstage periods, increased morbidity, and a high 5-years mortality rate of up to 25%. These limitations have driven research into alternative approaches, such as intra-articular antibiotic (IAA) irrigation, which uses a specialized titanium spacer for localized antibiotic delivery over a 7-day period. Case Report: A 53-year-old male with chronic PJI of the left knee underwent a novel rapid two-stage exchange arthroplasty using an IAA irrigation system. The first stage involved implant removal and placement of a specialized antibiotic delivery IAA device. During the 7-day interstage period, high-concentration local antibiotics (tobramycin and vancomycin) were administered. The second stage, performed 1 week later, included reimplantation with a total stabilized revision knee system. At 1-year post-surgery, the patient demonstrated excellent functional recovery, pain-free mobility, and no signs of recurrent infection. Conclusion: This case illustrates the potential of IAA in managing chronic PJI, offering rapid reimplantation and effective infection control. While promising, larger studies are needed to establish long-term efficacy and cost-effectiveness of this innovative approach.
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