Evidence map›Paper›PMID 40520701›Full record

ArticleFood chemistry: X2025

Rapid screening and taste mechanism of novel umami peptides from natural tripeptide database.

Jing Lan, Yongzhao Xiong, Kuo Dang, Daodong Pan, Lihui Du, Yanli Wang, Yali Dang

Abstract read
In one paragraph

Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing LanCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Yongzhao XiongCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Kuo DangCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Daodong PanCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Lihui DuCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Yanli WangCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.
Yali DangCollege of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small peptides, particularly tripeptides, play a crucial role in food umami taste. To dig for more umami tripeptides, the novel tripeptides pharmacophore model was established to rapidly screen umami peptides from natural tripeptide database. Twenty peptides with potential umami characteristics from 8000 tripeptides were further screened by molecular docking. The electronic tongue analysis and sensory evaluation suggested that the 20 tripeptides exhibited umami taste characteristics. The thresholds of the 20 tripeptides spanned from 0.137 to 2.237 mmol/L. Molecular dynamics simulations were used on T1R1 and four tripeptides with high umami intensity to reveal their taste mechanisms. In this study, a new screening strategy was established and 20 new umami tripeptides were identified and validated, providing a theoretical reference for rapid screening of umami tripeptides.

Indexed as

Common characteristic pharmacophoreMolecular dockingMolecular dynamics simulationRapid virtual screeningUmami tripeptides

Identifiers

PMID40520701
PMCPMC12166769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.