ArticleJournal of cytology
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Cytology: Navigating the Diagnostic Challenge between Tuberculosis and Sarcoidosis in Endemic Regions.
Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Acute mediastinitis, mediastinal granuloma, and fibrosing mediastinitis: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) plays an important diagnostic role in concealed pulmonary diseases. However, diagnosing sarcoidosis and differentiating it from tuberculosis is a diagnostic quandary. We, thus, aimed to evaluate EBUS-TBNA cytology in these cases in a tubercular-endemic zone. Methods: A prospective 5-year study was done in a tertiary care center on 118 patients with tuberculosis versus sarcoidosis with mediastinal lymphadenopathy who underwent EBUS-TBNA. All samples obtained were sent for cytomorphological and microbiological evaluation. On cytology analysis, demonstration of acid-fast bacilli was considered diagnostic of tuberculosis. However, in its absence, a multidisciplinary diagnostic (MDD) approach was followed to establish a diagnosis. Results: EBUS-TBNA cytology contributed in reaching the final diagnosis in 88.1% cases. Of the 55 cases of tuberculosis, cytomorphological features were contributory in 90.9% cases. Out of 29 cases of sarcoidosis, 24 showed granulomas. Microbiological tests were contributory in the final diagnosis of tuberculosis in only 21.8% cases as compared to 90.9% by cytology analysis. In 10 cases, a definitive diagnosis could not be made on cytology analysis and were finally diagnosed on the basis of MDD. A definitive distinction between tuberculosis and sarcoidosis could not be made despite MDD in four cases. Conclusion: While a diagnosis of tuberculosis can be made independently on cytological features, MDD with contributory cytological findings is essential for the diagnosis of sarcoidosis. EBUS-TBNA cytology, thus, plays an important role in the multidisciplinary strategy of approaching thoracic lesions.
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