ArticleChemistry of materials : a publication of the American Chemical Society2025
Flame-Made Doped Iron Oxide Nanoparticles as Tracers for Magnetic Particle Imaging.
Article in Chemistry of materials : a publication of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Effect of Cellulose Nanofiber Length on Magnetic Separation Performance and Biotin-Streptavidin Conjugation Efficiency of CNF/FeBiomacromolecules · 2026Article
- Preparation and Characterization of Coated ZnFeACS omega · 2026Article
- TriMag Microrobots: 3D-Printed Microrobots for Magnetic Actuation, Imaging, and Hyperthermia.Advanced materials (Deerfield Beach, Fla.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Magnetic particle imaging (MPI) is an emerging imaging modality that shows potential in tumor imaging, cell tracking, and angiography. It uses the signal generated from superparamagnetic iron oxide nanoparticles (SPIONs) with zero attenuation in tissue, showing excellent sensitivity and contrast. MPI resolution and sensitivity are dependent on the nonlinear dynamic magnetization of the SPION tracer and can be improved by tuning their magnetic properties. Doping SPIONs with manganese or zinc is an effective and biocompatible route to modify the magnetic properties of SPIONs. This study developed SPIONs doped with manganese or zinc as MPI tracers using flame spray pyrolysis (FSP), a highly scalable synthesis technique. The MPI performance was evaluated with a MOMENTUM imager. Postsynthesis citrate coating and filtration significantly enhanced the MPI resolution of SPIONs. The Zn-doped SPIONs exhibited the best resolution, while Mn-doped SPIONs showed the highest sensitivity. The overall MPI performance of all tracers was closely linked to their magnetic diameter and susceptibility, but deviated noticeably from the predictions of the Langevin model. Zn-doped SPIONs were encapsulated in a water-dispersible nanocarrier using flash nanoprecipitation (FNP), circumventing the need for citrate coating while preserving MPI performance. These findings show that the hydrodynamic size, size distribution, and composition of the SPIONs are critical to MPI performance and highlight the potential of combining FSP and FNP for large-scale production of the MPI tracers.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.