ArticleFrontiers in neurology2025
A nomogram model for prognosis of acute ischemic stroke treated with recombinant tissue-type plasminogen activator.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the predictive performance of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio for three-month poor functional outcome in ischemic stroke: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- Far-infrared irradiation restores mitochondrial dynamics to ameliorate ischemic stroke.Neural regeneration research · 2026Article
- Systemic inflammation response index as an independent predictor of unfavorable prognosis and its application in risk stratification in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neuroscience · 2026Article
- PAI-1, MMP-9, and NLR combined with NIHSS for predicting 90-day poor functional outcome in elderly acute ischemic stroke: a prospective observational cohort study.Frontiers in neurologyArticle
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Authors and funding
4 authors.
Funding
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Abstract
Objective: The primary objective of this study was to systematically assess the prognostic utility of neutrophil-derived inflammatory indices-specifically the neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation response index (SIRI)-and subsequently develop a predictive model for thrombolysis outcomes through the integration of these hematological biomarkers with clinical parameters, including acute-phase neurological severity (as quantified by baseline National Institutes of Health Stroke Scale [NIHSS] scores) and therapeutic timeliness (door-to-needle time, DNT) in acute ischemic stroke patients receiving recombinant tissue plasminogen activator (rt-PA) therapy. Methods: This retrospective cohort study analyzed consecutive patients with AIS who received intravenous thrombolysis with rt-PA at the First People's Hospital of Chuzhou in Anhui Province, China, between January 2021 and July 2023. Peripheral blood samples were collected within 24 h of admission to evaluate the NLR and SIRI. Univariate and multivariate logistic regression models were employed to assess the associations of NLR, SIRI, NIHSS score at admission, and DNT with short-term prognosis after intravenous thrombolysis for acute cerebral infarction. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive capacity of the NLR, SIRI, NIHSS scores, DNT for clinical outcomes in AIS patients. Results: A total of 232 AIS patients treated with rt-PA IVT completed the 3-month follow-up. Multivariate logistic regression confirmed NIHSS score, DNT time, NLR, and SIRI as independently associated with worse prognosis (all Conclusion: This study affirms that specific inflammatory markers like NLR and SIRI, alongside initial stroke severity and treatment timeliness, emerge as significant prognosis predictors in thrombolysis-treated stroke patients. By amalgamating these biomarkers, the proposed nomogram empowers clinicians to foresee and manage patient outcomes more effectively.
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