ArticleComputational and structural biotechnology journal2025
Integrated transcriptome and proteome analysis identifies keratins as key regulators of corneal scarring in a murine model.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Regulation of Keratin Chemical Modifications: Potential Molecular Mechanisms in Proliferative Diseases.International journal of molecular sciences · 2026Review
- Unbiased Long-Read Whole-Genome Sequencing Enables High-Resolution Mapping of Transgene Concatenation and Off-target Genomic Disruption in a Mouse Model.Computational and structural biotechnology journal · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
To elucidate the mechanism underlying corneal scarring, a murine model of corneal scarring was subjected to transcriptomic and proteomic analyses to explore changes in mRNA and protein levels during scar formation. A surgical model of stromal injury was established, and corneal tissue was harvested 3 weeks post-wounding and subjected to RNA sequencing and tandem mass tag proteomics. A total of 420 differentially expressed genes and 463 differentially expressed proteins were detected, of which 54 were commonly altered. Integrated Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed the predominant involvement of the regulation of actin cytoskeleton organization, cell metabolism, and regulation of inflammatory responses in the scarring process. To further explore the identified gene and protein interactions, we constructed a protein-protein interaction network that highlighted four keratin (Krt) genes (
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