Evidence map›Paper›PMID 40520575›Full record

ArticleMolecular therapy. Oncology2025

Targeted expansion of cytotoxic T cells using IL-12 and CD137L supplementation enhances antitumor efficacy.

Marta Sanz, Brendan T Mann, Elyse K McMahon, Alberto Bosque, Samuel Simmens, Natalia Soriano-Sarabia

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marta SanzDepartments of Microbiology Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Brendan T MannDepartments of Microbiology Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Elyse K McMahonDepartments of Microbiology Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Alberto BosqueDepartments of Microbiology Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Samuel SimmensBiostatistics, George Washington University, Washington, DC 20037, USA.
Natalia Soriano-SarabiaDepartments of Microbiology Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing success of allogenic Vδ2 T cell immunotherapy for the treatment of cancer has been demonstrated in recent studies. Vδ2 T cells recognize phosphoantigens, intermediates of the mevalonate pathway, through butyrophilin molecules, and they are not major histocompatibility complex (MHC) restricted. Allogeneic transfer of

Indexed as

alendronatecancerCD137Lcell therapycytotoxicityexpansiongamma delta T cellsMT: Regular IssueoncologyVd2 cells

Identifiers

PMID40520575
PMCPMC12166812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.