ArticleMaterials today. Bio2025
Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A multifunctional MOF-mineralized conductive hydrogel coating on zinc implants orchestrates neuro-osteogenic coupling for enhanced bone defect repair.Bioactive materials · 2027Article
- A Cascade Catalytic Nanoplatform Enabling PTT/CDT Synergistic Antibacterial and Heat-Triggered NO Release for Angiogenesis in Diabetic Wound Healing.International journal of pharmaceutics: X · 2026Article
- Review
- Advances in MOF-Based Transdermal Drug Delivery Systems: Mechanisms, Applications, and Future Prospects.Topics in current chemistry (Cham) · 2026Review
- Multifunctional Strontium-Substituted Hydroxyapatite/Polydopamine Photothermal Coating for Enhancing Antibacterial Activity and Osteoblast Response of Porous Tantalum Implants.Materials (Basel, Switzerland) · 2026Article
- Bioactive Hydrogel-MOF Composites as Resistance-Modulating Wound Interfaces: Molecular Mechanisms and Rational Design for Chronic Wound Management.Gels (Basel, Switzerland) · 2026Review
- Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions.Gels (Basel, Switzerland) · 2026Review
- Advanced Functional Wound Dressings in Precision Surgery: Immunometabolic Reprogramming, Bioadaptive Biomaterials, and Intelligent Regenerative Interfaces.International journal of molecular sciences · 2026Review
- Converging chemistry and clinical orthopedics in the emerging role of MOFs in advanced bone defect repair.Theranostics · 2026Review
- Hydrogel-Based Immunomodulatory Strategies for Infected Bone Defects Regeneration: Remodeling the Osteoimmune Microenvironment and Future Perspectives.International journal of nanomedicine · 2026Review
- Regulation of bone immunity by metal ions: a review of mechanisms and application progress.Frontiers in immunology · 2026Review
- ZIF-8-Based Nanomedicine for Bone Regeneration: A Critical Appraisal of Preclinical Osteoimmunomodulatory Evidence and Translational Readiness.International journal of nanomedicine · 2026Review
- Multifunctional Metal Composite Hydrogels for Diabetic Wound Therapy.Gels (Basel, Switzerland) · 2025Review
- Functionalized metal-organic framework and MOF-derived materials for bone regeneration applications.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe tissue dysfunction in diabetic patients has been a challenging clinical problem. Both bacterial infections and chronic inflammation contribute to diabetic microenvironmental disorders and poor tissue regeneration. In this paper, a composite hydrogel (Gelma@Sr-ZIF-8) was prepared by incorporating a strontium (Sr)-doped metal-organic framework (Sr-ZIF-8) into Gelatin methacryloyl (Gelma) hydrogel, which could reverse diabetic microenvironmental disorders and promote tissue regeneration in diabetic wounds. The zinc ions released from this hydrogel directly killed invading planktonic bacteria and inhibited biofilm formation. Moreover, zinc ions can disrupt biofilm structure, penetrate bacteria and remove biofilm. In addition, strontium and zinc ions reversed the pro-inflammatory immune microenvironment by modulating redox balance, restored phagocytosis by macrophages, and killed bacteria released from mature biofilms. In addition, strontium ions promote the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and promote the regeneration of blood vessels at the site of bone defects, ultimately promoting the regeneration of diabetic tissue. The synergistic effect of zinc and strontium ions gives Gelma@Sr-ZIF-8 excellent full-stage antibacterial and immunomodulatory properties. In vitro and in vivo studies have shown that Gelma@Sr-ZIF-8 can remodel the disturbed diabetic microenvironment, ultimately improving the efficacy of antimicrobial therapy and promoting diabetic tissue regeneration.
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