Evidence map›Paper›PMID 40520526›Full record

ArticleJournal of fluorine chemistry2024

Two F-18 radiochemistry methods to synthesize a promising transient receptor potential canonical 5 (TRPC5) radioligand.

Yanbo Yu, Sandip B Jadhav, Zhimin Xing, Hao Jiang, Lin Qiu, Tianyu Huang, Joel S Perlmutter, Zibo Li, Zhude Tu

Abstract read
In one paragraph

Article in Journal of fluorine chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanbo YuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Sandip B JadhavDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Zhimin XingDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Lin QiuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Zibo LiDepartment of Radiology, University of North Carolina at Chapel Hill, ChapelHill, NC 27599, USA.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.

Funding

PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
S1PR1-targeted PET imaging to predict and monitor response to HER2-targeting antibody-drug conjugatesR21CA291680 · NCI · WASHINGTON UNIVERSITY · PI RIBEIRO PEREIRA, PATRICIA MANUELA, TU, ZHUDE · 2024 to 2024
$400k
NCI NIH HHS R21 CA291680NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS134586
6 · The paper itself

Abstract

TRPC5 is a member of the mammalian transient receptor potential (TRP) channel superfamily and it has been implicated in various physiological and pathological mechanisms of neurological and psychiatric diseases. Fluorine-18 is one of the most widely used radionuclides for PET imaging due to its favorable chemical characteristics and nuclear-physical properties. Herein, we describe two complementary radiosynthetic approaches and preliminary

Indexed as

Fluorine -18PET tracerRadiolabelingTRPC5

Identifiers

PMID40520526
PMCPMC12161451

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.