SynthesisFrontiers in neuroscience2025
Long-term neurocognitive and behavioral outcomes in survivors of pediatric brain tumors: a systematic review.
Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Gray Matter Volumetry and Cognitive Functioning in Pediatric Posterior Fossa Tumor Survivors.Cancers · 2026Article
- Varied effectiveness of outpatient rehabilitation interventions in reducing long-term complications following childhood brain tumours: a systematic review.Frontiers in rehabilitation sciences · 2026Article
- Chemotherapy in adult patients with pilocytic astrocytoma: a retrospective multicenter cohort study.Journal of neuro-oncology · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Brain tumors are among the most common neoplasms in children. These patients suffer from neurocognitive impairment, treatment-related side effects, and experience a subpar quality of life (QoL), affecting academic endeavors, social interaction, and mental wellbeing. Methods: This review investigated different long-term neurocognitive and behavioral outcomes in pediatric brain tumor survivors and evaluated various effective treatment methods. We identified 75 relevant articles published between 2019 and 2024 using PubMed, PMC, Embase, and Google Scholar databases. Duplicates were removed, and 14 studies were finally selected following the PRISMA guidelines. Initial observations noted significant variations in the study methodologies and inclusion criteria. Results: Our study showed that children treated with proton radiotherapy experienced better neurocognitive and academic results than those treated with photon radiotherapy. Cognitive abilities were affected irrespective of the treatment, especially in early stage radiotherapy. Psychosocial impacts such as low self-esteem, depressive symptoms, and increased suicidal ideation were also demonstrated. Improvement in long-term outcomes was noted within therapeutic plans devoid of delayed high-dose radiotherapy and marrow ablation chemotherapy. Discussion: Increasing our understanding of the long-term effects associated with brain tumors using our current treatment methodology will help us formulate better treatment protocols and improve survivors' quality of life.
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Registered trials
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