ArticleAlzheimer's & dementia (New York, N. Y.)
The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12-month randomized trial.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04048759 (The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome
Who cites it
2 citing papers in PubMed.
- Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.Journal of intellectual disability research : JIDR · 2026Trial
- The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12-month randomized trial.Alzheimer's & dementia (New York, N. Y.)Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Participation in moderate-to-vigorous physical activity (MVPA) may prevent or delay the onset of AD. Therefore, we evaluated the potential effectiveness of a remotely delivered home-based group exercise (≈8/group) to increase daily MVPA and cardiorespiratory fitness in adults with DS to a level that may be associated with delaying AD in adults with DS.
methodsAdults with DS (
resultsParticipant retention at 12 months was 100%. Attendance at exercise and support/education sessions averaged ~85% and ~86%, respectively. Linear mixed modeling revealed no significant differences in change in MVPA from baseline to 12 months between the RH (10 min/day) and the RL arms (2 min/day, DISCUSSION: Our results suggest that remotely delivered group exercise (3 times/week) in conjunction with twice-monthly support/education is feasible and may increase daily MVPA and cardiorespiratory fitness to a level that may be associated with improvements in health and cognitive parameters in adults with DS. CLINICAL TRIALS REGISTRATION: This trial was approved by the Institutional Review Board at the University of Kansas Medical Center and was registered on clinicaltrials.gov (NCT04048759). Highlights: Evidence suggests that exercise may delay Alzheimer's disease (AD) in the general population, but its impact on adults with Down syndrome (DS) remains unknown.Adults attended remote exercise sessions either 1 or 3 times a week or received basic education about exercise.Those who attend exercise sessions 3 times a week increased their physical activity by 70 min per week.Those who attend exercise sessions 3 times a week improve their cardiorespiratory fitness.Remote exercise can be used in future AD prevention trials in adults with DS.
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