Evidence map›Paper›PMID 40520467›Full record

ArticleFrontiers in genome editing2025

Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage.

Meredith K Loth, Kendall T Mesch, Celine Herrera-Garcia, Liza E Brusman, Zoe R Donaldson

Abstract read
In one paragraph

Article in Frontiers in genome editing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Meredith K LothDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States.
Kendall T MeschDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States.
Celine Herrera-GarciaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States.
Liza E BrusmanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States.
Zoe R DonaldsonDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States.

Funding

TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9M
Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
NIDA NIH HHS T32 DA017637NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607
6 · The paper itself

Abstract

Prairie voles (

Indexed as

Avpr1aCRISPRaCRISPRiDrd1Drd2Oxtrprairie volessomatic gene regulation

Identifiers

PMID40520467
PMCPMC12162470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.