Evidence map›Paper›PMID 40520466›Full record

ArticlePain research & management2025

Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain.

Xiuzhi Wang, Yipeng Le, Xichen Wang, Yingchao Song, Qian Su, Xiaoxiao Xiao, Yifan Li, Wen Qin, Chunshui Yu, Meng Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain research & management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiuzhi WangSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0003-4107-3073
Yipeng LeSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0009-0008-1918-1354
Xichen WangSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0009-0008-1819-4727
Yingchao SongCollege of Artificial Intelligence and Big Data for Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong 250117, China.ORCID 0000-0001-6857-0657
Qian SuDepartment of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for China, Tianjin 300060, China.ORCID 0000-0001-5828-1683
Xiaoxiao XiaoSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0003-0867-5144
Yifan LiSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0009-0004-9513-629X
Wen QinDepartment of Radiology, State Key Laboratory of Experimental Hematology, Tianjin Key Lab of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China.ORCID 0000-0002-9121-8296
Chunshui YuSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0001-5648-5199
Meng LiangSchool of Medical Technology, School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0003-0916-520X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain is a prevalent and debilitating condition that imposes substantial personal and societal burdens. Despite its significance, the neural mechanisms underlying individual susceptibility to chronic pain remain inadequately understood. In this study, we examined the prospective associations between 1325 brain structural imaging phenotypes and the future risk of developing chronic pain in a UK Biobank cohort of 5754-5756 participants. These phenotypes encompassed regional and tissue volume, cortical surface area and thickness. General linear models (GLMs) were employed to identify brain structural variations associated with the risk of developing chronic pain, and then Mendelian randomization (MR) was employed to explore potential causal relationships between brain structure and chronic pain development. GLMs identified three significant associations between imaging phenotypes and the future development of chronic pain. All three imaging phenotypes pertained to the cortical surface area of the frontal operculum, albeit derived from three different brain atlases. Specifically, reduced cortical surface area in the frontal operculum was significantly associated with an increased risk of developing chronic pain: BA atlas area 44 (

Indexed as

Chronic PainFrontal LobeAdultAgedCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMendelian Randomization AnalysisMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID40520466
PMCPMC12163224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.